Borrelia miyamotoi en Relapsing Fever in verschillende landen
12 januari 2021Review
: 'Borrelia miyamotoi - An Emerging Human Tick-Borne Pathogen in Europe' by Katarzyna Kubiak, Magdalena Szczotko, and Małgorzata Dmitryjuk; Bron https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827671/Borrelia miyamotoi in Europa
; Bron 'Table 1'
..Worldwide, B. miyamotoi prevalence in questing Ixodes ticks ranges from 0.2 to 10% [42,43,44,77,82]. This pathogen has been detected in all three tick life stages (larvae, nymphs and adults) [68,83,84]. In European populations of I. ricinus,
B. miyamotoi was identified in 0.1-2% larvae [78,85], 0.4-2.8% nymphs [12,36,78,79] and 3.0-4.3% of adults [78,79]
'Borrelia miyamotoi: Should this pathogen be considered for the diagnosis of tick-borne infectious diseases in Spain?' by Ana M Palomar, Aránzazu Portillo, Paula Santibáñez, Sonia Santibáñez, José A Oteo; Bron https://pubmed.ncbi.nlm.nih.gov/29187292/
van de met Borrelia geïnfecteerde teken
droegen B. miyamotoi
en 87,1% Borrelia burgdorferi sensu lato
'Prevalence and diversity of Borrelia species in ticks that have bitten humans in Sweden' by Peter Wilhelmsson, Linda Fryland, Stefan Börjesson, Johan Nordgren, Sven Bergström, Jan Ernerudh, Pia Forsberg, Per-Eric Lindgren; Bron https://pubmed.ncbi.nlm.nih.gov/20844223/
van de met Borrelia geïnfecteerde teken droegen B. miyamotoi
en 99% Borrelia burgdorferi sensu lato
'Borrelia miyamotoi and Borrelia burgdorferi (sensu lato) identification and survey of tick-borne encephalitis virus in ticks from north-eastern Germany' by Cristian Răileanu, Oliver Tauchmann, Ana Vasić, Elisabeth Wöhnke, Cornelia Silaghi; Bron https://pubmed.ncbi.nlm.nih.gov/32106890/
Resultaten: ongeveer 25%
van de met Borrelia geïnfecteerde teken droegen B. miyamotoi
en 75% Borrelia burgdorferi sensu lato
Publicatie - 'Borrelia miyamotoi in vectors and hosts in The Netherlands'; Bron https://pubmed.ncbi.nlm.nih.gov/28065617/
Out of 3360 unfed (or questing) nymphs, 313 (9.3%) were infected with B. burgdorferi s.l., 70 (2.1%) were infected with B. miyamotoi, and 14 (0.4%) were co-infected with B. burgdorferi s.l. and B. miyamotoi. Co-infection of B. burgdorferi s.l. with B. miyamotoi occurred more often than expected from single infection prevalences (p=0.03).
Artikel Biowetenschap en maatschappij (2020) - 'Koorts na een tekenbeet – soms iets anders dan lymeziekte?' over Borrelia miyamotoi; Bron https://www.biomaatschappij.nl/koorts-n ... ymeziekte/België en Nederland
Publicatie - 'The presence of Borrelia miyamotoi, a relapsing fever spirochaete, in questing Ixodes ricinus in Belgium and in The Netherlands'; Bron https://www.researchgate.net/publicatio ... etherlands
In this study, we show the results of PCR screenings for B. miyamotoi in flagged Ixodes ricinus from Belgium and the Netherlands. B. miyamotoi was detected in nine of thirteen, and three of five locations from the Netherlands and Belgium, respectively. These outcomes indicate that B. miyamotoi is more spread than previously thought. The mean infection rate
B. miyamotoi was 1.14% for Belgium and 3.84% for the Netherlands.
Joseph J. Burrascano Jr - Making Rational Choices when Testing for Tick-Borne Diseases - Ilads 2020; Bron https://www.ilads.org/ilads-conference/ ... g-rational
DIVERSITY OF TICK-BORNE PATHOGENS- Need to test for co-infections
In a 2018 study that tested ticks submitted by patients to Igenex, 11.3% contained Lyme Borrelia, 3.4% contained tick-borne relapsing fever (TBRF) Borrelia, 3.3% contained Rickettsia, 2.4% contained Babesia, 2.1% contained Ehrlichia and 0.4% contained Bartonella.
A concurrent study in which over 10,000 patient samples tested by Igenex were reported, 37.3% were positive for Babesia species, 32.1% for Lyme Borrelia, 27.7% for TBRF, 19.1% for Bartonella, 16.7% for Anaplasma, 12.8% for Rickettsia and 6.9% for Ehrlichia. Positives were found in patient specimens from nearly every state.
Igenex immunoblots for Lyme Borrelia are able to detect antibodies to eight distinct strains and species, and when tested using validation samples from the CDC, New York, California, the CAP and NY Biologicals, sensitivity was 100% when interpreted with Igenex interpretative criteria, and 89% with CDC criteria. Specificity was 97% when using Igenex criteria and 99.3% when using CDC criteria. Because not every patient generates detectable levels of antibody, adding PCR testing in this cohort can increase disease detection by 12% (294 specimens tested).
Igenex immunoblots for TBRF are able to detect antibodies to six distinct species of TBRF. In well-characterized, PCR-positive patient samples, sensitivity was 100% (convalescent serum) and testing using a wide variety of specimen types revealed 97% specificity.
; Bron https://www.iddoctor.eu/docs/Crypto-Inf ... ambert.pdf
15 april 2019
'Metagenomic 16S rRNA gene sequencing survey of Borrelia species in Irish samples of Ixodes ricinus ticks' by John S. Lambert, Michael John Cook, John Eoin Healy, Ross Murtagh, Gordana Avramovic, Sin Hang Lee; Bron https://journals.plos.org/plosone/artic ... ne.0209881
Questing Ixodes ricinus nymph samples were taken at six localities within Ireland.
The overall rate of borrelial infection in the Irish tick population was 5%, with a range from 2% to 12% depending on the locations of tick collection. The most prevalent species detected was B. garinii (70%) followed by B. valaisiana (20%) and B. miyamotoi (10%).
Red Laboratories - 'Are we looking at the wrong culprit'?: Bron https://www.ilads.org/ilads-conference/ ... se-culprit
en Bron https://www.iddoctor.eu/docs/Crypto-Inf ... atovic.pdf
en Bron https://www.youtube.com/watch?v=Mr2hKGOjCZM
er is in 2020 gerapporteerd dat 60%
van de teken
die zij hebben getest positief waren voor Borrelia miyamotoi-fagen
terwijl slechts 15%
positief was voor Borrelia burgdorferi sensu lato-fagen
en de percentages overeen kwamen met de resultaten van de geteste samples (bloed, urine, speeksel) van mensen uit verschillende landen in Europa en de VS.
Pathogens found in positive ticks:
Borrelia burgdorferi sl: 17% pos
Borrelia miyamotoi: 60% pos
Borrelia Relapsing Fever Group 23% pos
25% of positive ticks were for 2 pathogens
Unexpected high rate of B. miyamotoiand Relapsing Fever Borrelia Phages in tested ticks.
This result is in line with those obtained on human samples:
Since July2019, over 2100 results from patients originating various countries have been obtained.
Testing included mainly late stage/chronic patients and the aggregated data are showing 30% negative results and 70% positive among which over 60% indicated the presence of specific Borrelia miyamotoi phages.
With respect to the obtained results, a question raised: are we searching for the wrong culprit with Lyme-disease testing?
Interessant is wat het antwoord op de gestelde vraag zal gaan worden. Is het juist of onjuist?